Series episode
| Donnie Wahlberg | ... | Danny Reagan |
| Bridget Moynahan | ... | Erin Reagan-Boyle |
| Will Estes | ... | Jamie Reagan |
| Len Cariou | ... | Henry Reagan |
| Tom Selleck | ... | Frank Reagan |
| Jennifer Esposito | ... | Jackie Curatola |
| Bobby Cannavale | ... | Charles Rosselini |
| Amy Carlson | ... | Linda Reagan |
| Nicholas Turturro | ... | Sgt. Anthony Renzulli |
| Sam Robards | ... | Roger |
| Amy Wilson | ... | Elaine |
| Ryann Shane | ... | Chloe |
| Olga Merediz | ... | Inez |
| Jason Jurman | ... | Jeffrey |
| Sami Gayle | ... | Nicky Reagan-Boyle |
| Khan Baykal | ... | Lizard |
| Paige Turco | ... | Detective Ryan |
| Annie Q. | ... | Lila |
| Brad Calcaterra | ... | Taze |
| Todd Faulkner | ... | TARU Officer |
| David Shih | ... | CSU Tech |
| John Bedford Lloyd | ... | Vincenzo |
| James Thomas Bligh | ... | Police Officer |
| Edgar Felix | ... | Priest |
| Jeff Grossman | ... | Police Officer |
| Abigail Hawk | ... | Detective Melissa Baker |
| Derek Hedlund | ... | Officer Wilson |
| Tracy Howe | ... | Rory Brennan |
| Patricia Kalember | ... | Dr. Keller |
| Mark Margolis | ... | Whitey Brennan |
| James Meddock | ... | Lincoln Jones |
| Stephane Nicoli | ... | Student |
| Nneoma Nkuku | ... | Easter |
| Kevin O'Rourke | ... | Monseignior Doonan |
| Otto Sanchez | ... | Diego |
| Andrew Terraciano | ... | Sean Reagan |
| Tony Terraciano | ... | Jack Reagan |
| Lucy Walters | ... | Vanessa |
| Jessica Hoffman | ... | Girl In Deli |
| Alex Ziwak | ... | Undercover Detective |
| John Polson | ... | Direction |
| Diana Son | ... | Script |