Series episode
| Donnie Wahlberg | ... | Danny Reagan |
| Bridget Moynahan | ... | Erin Reagan-Boyle |
| Will Estes | ... | Jamie Reagan |
| Len Cariou | ... | Henry Reagan |
| Tom Selleck | ... | Frank Reagan |
| Jennifer Esposito | ... | Jackie Curatola |
| Amy Carlson | ... | Linda Reagan |
| Nicholas Turturro | ... | Sgt. Anthony Renzulli |
| Kevin O'Rourke | ... | Mons. Walter Donahue |
| John Bedford Lloyd | ... | Vincenzo |
| Jack Gwaltney | ... | Kevin Brennan |
| E.J. Bonilla | ... | Julio |
| Sami Gayle | ... | Nicky Reagan-Boyle |
| Patricia Kalember | ... | Dr. Keller |
| Otto Sanchez | ... | Diego |
| Tracy Howe | ... | Rory Brennan |
| Mark Margolis | ... | Whitey Brennan |
| Tony Terraciano | ... | Jack Reagan |
| Andrew Terraciano | ... | Sean Reagan |
| Abigail Hawk | ... | Detective Melissa Baker |
| James Nuciforo | ... | Escort |
| Nneoma Nkuku | ... | Easter |
| A.C. Davison | ... | Pete Johnson |
| Victor Verhaeghe | ... | Dave Greenwald |
| ... | Karl | |
| ... | Esteban | |
| Ernesto Rosas | ... | Bartender |
| Fiona Choi | ... | Tech |
| Mark Zeisler | ... | President Travis |
| Jim Ireland | ... | Dr. Barnard |
| Mikhael Bassilli | ... | Amir |
| Peter Conboy | ... | New York City Police Officer |
| Gina Hernandez | ... | Detective |
| Luis Ayala | ... | Bar Patron |
| Jennifer Butler | ... | Detective |
| Mike Catapano | ... | Escorting Officer |
| Scott Churchson | ... | Priest |
| Bryan Dechart | ... | Photographer |
| Edgar Felix | ... | Priest |
| Derek Hedlund | ... | Guarding Officer |
| Jan Eliasberg | ... | Direction |
| Kevin Wade | ... | Script |