Series episode
Cast: (20 - show/hide all)
| Jonny Lee Miller | ... | Sherlock Holmes |
| Lucy Liu | ... | Dr. Joan Watson |
| Jon Michael Hill | ... | Detective Marcus Bell |
| Desmond Harrington | ... | Michael |
| Aidan Quinn | ... | Captain Thomas 'Tommy' Gregson |
| Mike Doyle | ... | Chris Holland |
| Juan Carlos Hernández | ... | Adrian Cruz |
| Michael Potts | ... | Doctor Peter Hanson |
| James Monroe Iglehart | ... | Detective Mason |
| Arnie Burton | ... | Paul Chambers |
| Gia Crovatin | ... | Marcy Nix |
| Geno Segers | ... | Fetu |
| Bruce Sabath | ... | David |
| Ron Menzel | ... | Brian |
| Kevin Ray | ... | Kevin |
| Ami Sheth | ... | Mrs. Holland |
| Robert Vincent Smith | ... | George Nix |
| Max Golub | ... | Colonial Soldier |
| Evelyn Liu | ... | NYPD Officer Garcia |
| Frankie Verroca | ... | Commune Old Hippie |
Crew:
| Christine Moore | ... | Direction |
| Jeffrey Paul King | ... | Script |