Series episode
| Freddie Highmore | ... | Dr. Shaun Murphy |
| Nicholas Gonzalez | ... | Dr. Neil Melendez |
| Antonia Thomas | ... | Dr. Claire Browne |
| Chuku Modu | ... | Dr. Jared Kalu |
| Beau Garrett | ... | Jessica Preston |
| Tamlyn Tomita | ... | Allegra Aoki |
| Hill Harper | ... | Dr. Marcus Andrews |
| Richard Schiff | ... | Dr. Aaron Glassman |
| Graham Verchere | ... | Young Shaun |
| Paige Spara | ... | Lea |
| Jasika Nicole | ... | Dr. Carly Lever |
| Tim Russ | ... | Chuck |
| Michael St. John Smith | ... | John Wannamaker |
| Angela Palmer | ... | Katt |
| Blair Penner | ... | SFPD Cop |
| Donald Sales | ... | Controller |
| Serge Jaswal | ... | Brad |
| Trent Redekop | ... | Cashier |
| Victoria Bidewell | ... | Liaison |
| Kirby Morrow | ... | Shaun's Father |
| William C. Vaughan | ... | Casper Deputy |
| Adam Lolacher | ... | Another Casper Deputy |
| Shiren Van Cooten | ... | Social Worker |
| Jesse Reid | ... | Surgical Resident |
| Beatrice Zeilanger | ... | Nurse Dina Vizcaino |
| Teryl Rothery | ... | JL |
| Taylor Hastings | ... | Surgical Assist |
| Angela Moore | ... | Nurse |
| Judith Maxie | ... | Chuck's Wife |
| Hector Johnson | ... | Chuck's Brother |
| Ken Do | ... | Handsome Young Man |
| Serena Bickerstaff | ... | Attractive Woman |
| Amelia Morris | ... | Wannamaker's Executive Assistant |
| John Dahl | ... | Direction |
| William Rotko Lloyd Gilyard Jr. | ... | Script |