Oscars:

Won Best Actress in a Leading Role:
The Silence of the Lambs (1991)

1. *Inside Man (2006) ... Madeleine White
   
2. Panic Room (2002) ... Meg Altman
   
3. Contact (1997) ... Eleanor Arroway
   
4. Nell (1994) ... Nell
   
5. Maverick (1994) ... Annabelle Bransford
   
6. Sommersby (1993) ... Laurel Sommersby
   
7. Little Man Tate (1991) ... Dede Tate
   Little Man Tate - vidunderbarnet
8. *The Silence of the Lambs (1991) ... Clarice Starling
   Ondskabens øjne
9. *Catchfire (1990) ... Anne Benton
   Forelsket i et offer
10. The Accused (1988) ... Sarah Tobias
    Anklaget
11. Bugsy Malone (1976) ... Tallulah
    
12. Taxi Driver (1976) ... Iris