| Demian Bichir | ... | Esteban Reyes (27 episodes) |
| Maulik Pancholy | ... | Sanjay (25 episodes) |
| Enrique Castillo | ... | Cesar (25 episodes) |
| Indigo | ... | Vaneeta (24 episodes) |
| Guillermo Díaz | ... | Guillermo (23 episodes) |
| Renee Victor | ... | Lupita (21 episodes) |
| Jack Stehlin | ... | Capt. Roy Till (18 episodes) |
| Hemky Madera | ... | Ignacio (17 episodes) |
| Martin Donovan | ... | Peter Scottson (14 episodes) |
| Becky Thyre | ... | Pam (13 episodes) |
| Matthew Modine | ... | Sullivan Groff (12 episodes) |
| Shoshannah Stern | ... | Megan (11 episodes) |
| Page Kennedy | ... | U-Turn (11 episodes) |
| Fatso-Fasano | ... | Marvin (10 episodes) |
| Bruce Nozick | ... | Whit Tillerman (9 episodes) |
| Eden Sher | ... | Gretchen (8 episodes) |
| Mary-Kate Olsen | ... | Tara Lindman (8 episodes) |
| Anthony Ledesma | ... | Bodyguard (8 episodes) |
| Jennifer Jason Leigh | ... | Jill Price-Gray (8 episodes) |
| Alanis Morissette | ... | Dr. Audra Kitson (8 episodes) |
| Michael Harney | ... | Det. Mitch Ouellette (8 episodes) |
| Ramón Franco | ... | Dirty Man (7 episodes) |
| Julie Bowen | ... | Lisa (7 episodes) |
| Hannah Marks | ... | Harmony (7 episodes) |
| Jillian Rose Reed | ... | Simone (7 episodes) |
| Pablo Schreiber | ... | Demetri (7 episodes) |
| Tressa DiFiglia | ... | Maggie (6 episodes) |
| Meital Dohan | ... | Yael Hoffman (6 episodes) |
| Jamie Denbo | ... | Raylene (6 episodes) |
| Shawn Schepps | ... | Alison (5 episodes) |
| David Doty | ... | Principal Dodge (5 episodes) |
| Tracii Show | ... | Jada Henderson (5 episodes) |
| Sammy Fine | ... | Benj (5 episodes) |
| Julanne Chidi Hill | ... | Clinique (5 episodes) |
| Joey Luthman | ... | Rad Ferris (5 episodes) |
| Larry Joe Campbell | ... | C.P. Jones (5 episodes) |
| Kate del Castillo | ... | Pilar Zuazo (5 episodes) |
| Roy Abramsohn | ... | Rick Levine (5 episodes) |
| Michelle Trachtenberg | ... | Emma Karlin (5 episodes) |
| Haley Hudson | ... | Quinn Hodes (4 episodes) |
