| Gina Ravera | ... | Detective Irene Daniels (42 episodes) |
| Jonathan Del Arco | ... | Dr. Morales (39 episodes) |
| Ryan Van de Kamp Buchanan | ... | Detective (27 episodes) |
| Mary McDonnell | ... | Captain Sharon Raydor (23 episodes) |
| Ransford Doherty | ... | Coroner's Investigator Kendall (21 episodes) |
| Frances Sternhagen | ... | Willie Ray Johnson (14 episodes) |
| James Avery | ... | Dr. Crippen (11 episodes) |
| Barry Corbin | ... | Clay Johnson (11 episodes) |
| Stephen Martines | ... | Ricardo Ramos (8 episodes) |
| Bob Clendenin | ... | Terrence (6 episodes) |
| Conan McCarty | ... | Detective Ross (6 episodes) |
| Steve Roussell | ... | Tactical Flight Officer (6 episodes) |
| Mark Pellegrino | ... | Gavin Q. Baker III (6 episodes) |
| James Patrick Stuart | ... | Deputy D.A. Garnett (5 episodes) |
| Kathe Mazur | ... | D.D.A. Andrea Hobbs (5 episodes) |
| Curtis Armstrong | ... | Peter Goldman (5 episodes) |
| Sosie Bacon | ... | Charlie (4 episodes) |
| Courtney B. Vance | ... | Chief Tommy Delk (4 episodes) |
| S. Epatha Merkerson | ... | Dr. Rebecca Dioli (3 episodes) |
| Patti Yasutake | ... | Cathy Tao (3 episodes) |
| Billy Burke | ... | Phillip Stroh (3 episodes) |
| Jeff Wolfe | ... | Police Uni (3 episodes) |
| Paola Turbay | ... | Det. Mikki Mendoza (3 episodes) |
| Quinton Lopez | ... | Ruben (3 episodes) |
| John Prosky | ... | Banks (2 episodes) |
| Amy Hill | ... | Franny (2 episodes) |
| Michael Woods | ... | FBI Agent Bill Blackburn (2 episodes) |
| Rosie Garcia | ... | Shy Girl (2 episodes) |
| Douglas Sills | ... | Dennis Dutton (2 episodes) |
| Jack Conley | ... | FBI Agent Jackson (2 episodes) |
| Lorraine Toussaint | ... | Deputy D.A. Powell (2 episodes) |
| Michael Kostroff | ... | Dr. Aaron Sands (2 episodes) |
| Ray Wise | ... | Tom Blanchard (2 episodes) |
| Mark Rolston | ... | Father Jack (2 episodes) |
| William Daniels | ... | Commissioner Andrew Schmidt (2 episodes) |
| Debra Mooney | ... | Elaine Donahue (2 episodes) |
| Paul Schulze | ... | Richard Branch (2 episodes) |
| James Carpinello | ... | Larry Cole (2 episodes) |
| Brady Smith | ... | Detective McHale (2 episodes) |
| Lisa Picotte | ... | Cynthia Donahue (2 episodes) |
