| Brent Huff | ... | Officer Smitty (14 episodes) |
| Ali Larter | ... | Dr. Grace Sawyer (13 episodes) |
| Harold Perrineau | ... | Nick Armstrong (10 episodes) |
| Zayne Emory | ... | Henry Nolan (8 episodes) |
| Currie Graham | ... | Ben McRee (7 episodes) |
| Sarah Shahi | ... | Jessica Russo (7 episodes) |
| Jasmine Mathews | ... | Rachel Hall (7 episodes) |
| Mircea Monroe | ... | Isabel (6 episodes) |
| Michael Beach | ... | Commander West (6 episodes) |
| Crystal Coney | ... | Nurse Lisa (6 episodes) |
| Dylan Conrique | ... | Tamara Collins (6 episodes) |
| Demetrius Grosse | ... | Det. Kevin Wolfe (5 episodes) |
| Bruce M. Stockert | ... | Doctor (5 episodes) |
| Brandon Routh | ... | Doug Stanton (5 episodes) |
| Toks Olagundoye | ... | Professor Fiona Ryan (5 episodes) |
| Sara Rue | ... | Nell (4 episodes) |
| Michelle Bernard | ... | Officer (4 episodes) |
| Matthew Glave | ... | Oscar Hutchinson (4 episodes) |
| Carsyn Rose | ... | Lila (4 episodes) |
| Madeleine Coghlan | ... | Abigail (4 episodes) |
| Daniel Lissing | ... | Sterling Freeman (4 episodes) |
| Annie Wersching | ... | Rosalind Dyer (4 episodes) |
| Miguel-Andres Garcia | ... | Track Suit Guy (3 episodes) |
| David DeSantos | ... | Det. Elijah Vestri (3 episodes) |
| Cameron J. Armstrong | ... | Nurse G. Brown (3 episodes) |
| Angel Parker | ... | Mrs. Grey (3 episodes) |
| Jane Daly | ... | Melanie Evers (3 episodes) |
| Enver Gjokaj | ... | Donovan (3 episodes) |
| Leslie A. Hughes | ... | Officer (3 episodes) |
| Kamar de los Reyes | ... | Ryan Caradine (3 episodes) |
| Arjay Smith | ... | James Murray (3 episodes) |
| Camille Guaty | ... | Sandra de La Cruz (3 episodes) |
| Hrach Titizian | ... | Ruben Derian (3 episodes) |
| Ryan Michelle Bathe | ... | Det. Paige (2 episodes) |
| Danny Nucci | ... | Det. Motta (2 episodes) |
| Debbie Fan | ... | Doctor (2 episodes) |
| Andre Franco | ... | Biker (2 episodes) |
| Tom McComas | ... | Steve (2 episodes) |
| Andrei Runtso | ... | Zach (2 episodes) |
| Atticus Batacan | ... | Clerk (2 episodes) |
