Series info
| Dylan Walsh | ... | Dr. Sean McNamara (1 episode) |
| Julian McMahon | ... | Dr. Christian Troy (1 episode) |
| John Hensley | ... | Matt McNamara (1 episode) |
| Joely Richardson | ... | Julia McNamara (1 episode) |
| Raymond Cruz | ... | Alejandro Pérez (1 episode) |
| Geoffrey Rivas | ... | Silvio Pérez (1 episode) |
| Robert LaSardo | ... | Escobar Gallardo (1 episode) |
| Ruth Williamson | ... | Hedda Grubman (1 episode) |
| Kelsey Batelaan | ... | Annie McNamara (1 episode) |
| Kelly Carlson | ... | Kimber Henry (1 episode) |
| Ara Celi | ... | Celia (1 episode) |
| Marlene Forte | ... | Miss Michaels (1 episode) |
| Joanna Sanchez | ... | Rosa (1 episode) |
| Roma Maffia | ... | Dr. Liz Cruz (1 episode) |
| Jeff Chase | ... | Jose (1 episode) |
| Karla Hernandez | ... | 8 Year Old Girl (1 episode) |
| Linda Klein | ... | Nurse Linda (1 episode) |
| Sal Lopez | ... | Julio Esperanza (1 episode) |
| Rob Macie | ... | Bartender (1 episode) |
| Grant Vaught | ... | Young Christian (1 episode) |
| Ryan Murphy | ... | Creator(s) |
| 4.01 | Cindy Plumb | |
| 4.02 | Blu Mondae | |
| 4.03 | Monica Wilder | |
| 4.04 | Shari Noble | |
| 4.05 | Dawn Budge | |
| 4.06 | Faith Wolper, PhD | |
| 4.07 | Burt Landau | |
| 4.08 | Conor McNamara | |
| 4.09 | Liz Cruz | |
| 4.10 | Merrill Bobolit | |
| 4.11 | Conor McNamara, 2026 | |
| 4.12 | Diana Lubey | |
| 4.13 | Reefer | |
| 4.14 | Willy Ward | |
| 4.15 | Gala Gallardo |