Series episode
| Gary Sinise | ... | Detective Mac Taylor |
| Melina Kanakaredes | ... | Detective Stella Bonasera |
| Carmine Giovinazzo | ... | Detective Danny Messer |
| Anna Belknap | ... | Detective Lindsay Monroe |
| Hill Harper | ... | Dr. Sheldon Hawkes |
| Eddie Cahill | ... | Detective Don Flack |
| Ron Yuan | ... | Dr. Evan Zao |
| David Julian Hirsh | ... | Zack Shannon |
| Peter Onorati | ... | Angelo Venetti Sr. |
| Joel Brooks | ... | Felix Parker |
| Rebecca Staab | ... | Jessica Freemont |
| Lesli Kay | ... | Tanya Danville |
| Gary Wolf | ... | Ryan Knight |
| Michelle Ewin | ... | Missy Freemont |
| Andrew Fiscella | ... | Mickey D' Amato |
| Ross Thomas | ... | Sam |
| Micah Femia | ... | Lead Teen Boy |
| Ellen Woglom | ... | Briana Freemont |
| Danielle McKee | ... | Lab Tech |
| Daniel Arrias | ... | Bobby Veneiti |
| Thomas Daniel | ... | Detective |
| Freddie De Grate | ... | Zookeeper |
| Norberto Barba | ... | Direction |
| Peter M. Lenkov Timothy J. Lea | ... | Script |